The Sealantis alga-mimetic adhesives present a true breakthrough in the realm of biosurgicals, providing a sophisticated tissue adhesive technology with superior efficacy, safety and ease of use. Mimicking the underwater adherence mechanism of algae, the Sealantis adhesive technology platform opens a gateway to a variety of potential applications in surgery, injuries, and drug delivery.
The platform comprises a protein-free adhesive based on Alginate, a natural polymer produced by algae.
The Sealantis alga-mimetic adhesive technology is a viable platform that can be utilized in a variety of indications, relevant to three major applications:
- Surgical sealing: In many types of surgical procedures, tissue reattachment techniques, such as suturing and stapling, are not leak-proof, resulting in possible leakage of body fluids during and after surgery. Sealantis develops sealants for surgical leakage control in cardio-vascular surgery, gastro-intestinal (GI) surgery and other surgical practices. .
- Adhesion prevention and tissue healing: Post-surgical adhesions are a common complication in many types of surgeries and in various orthopedic injuries. The formation of fibrous tissue (scars, adhesions) following trauma to tissues, severely damages the proper recovery and is a major problem from a clinical as well as an economical perspective. Sealantis develops an innovative approach for preventing adhesions and promoting the functional healing of internal tissues.
- Surgical adhesion: Using a tissue adhesive to reconnect two planes of tissue resolves an important clinical need, particularly in esthetic surgeries, such as face and body lifts in which large skin flaps must be reattached. Sealantis develops a unique solution for tissue adhesion and space-elimination in esthetic surgery.
- Site-specific drug delivery: The ability of Sealantis alga-mimetic adhesives to adhere to various internal tissues enables a new approach for the administration of drugs: site-specific drug delivery. By using the adhesive as a drug carrier, drug release can be confined to a specific target site. Site-specific drug delivery can decrease toxicity, increase efficacy and potentially modify bio-distribution.